Hempgan, an innovative health and wellness company, is revolutionizing the market with the introduction of CBG, or cannabigerol, into its products. But what exactly is CBG, and why is it gaining so much attention? Let’s explore this fascinating compound and its potential therapeutic uses that are transforming the way we manage our health.
Cannabigerol (CBG) is one of the many cannabinoids found in the cannabis plant, but unlike its more famous cousin THC, CBG is non-psychoactive. This means that it does not cause the “high” associated with cannabis use. In fact, CBG is often referred to as the “mother cannabinoid” because it is the precursor to other cannabinoids, such as CBD and THC, which are formed from it during the plant’s growth. Check out the following article to learn more:
All about CBG
Cannabigerol (CBG) is a non-intoxicating compound found in plants of the Cannabis genus, offering several applications for human health. In other words, CBG originates from hemp, does not cause psychoactive effects and can bring benefits to well-being, similar to CBD.
Known as “the mother of all cannabinoids”, CBG is the precursor to other cannabinoids, as they are all derived from its acidic form: cannabigerolic acid (CBGA). Like other cannabinoids, CBG acts as a phytocannabinoid, interacting with the body’s endocannabinoid system to help regulate and maintain homeostasis.

Researchers classify CBG as a minor cannabinoid because cannabis plants produce very small amounts of it compared to more well-known cannabinoids like CBD and THC. CBG typically makes up less than one percent of the total weight of the cannabis plant. However, CBGA is essential for the production of CBD and THC in the plant.
Although CBG, CBD, and THC all originate from the same compound, CBGA, the speed at which each develops in the Cannabis sativa plant varies. CBGA quickly converts to THC and CBD, leaving little CBGA available to convert to CBG, which explains why CBG is less popular and well-known than its counterparts.
In growing cannabis plants, enzymes convert most of the CBGA into cannabinoid acids: cannabidiolic acid (CBDA) and tetrahydrocannabinolic acid (THCA). Decarboxylation, a process that occurs when the plant is exposed to heat or ultraviolet light, turns these acids into CBD and THC. Decarboxylation can also convert CBGA into CBG, but on a much smaller scale.
As the cannabis plant matures, CBGA uses specific enzymes to synthesize CBDA, THCA, and cannabichromenic acid (CBCA). After this initial conversion, only small amounts of CBGA remain in a mature plant. When heated, these structures lose a carbon element and transform into their final forms: CBG, CBD, CBC, or THC.
CBD vs CBG what is the difference?
CBD (cannabidiol) and CBG (cannabigerol) are both cannabinoids found in the cannabis plant, but they have significant differences in terms of their origin, effects, and potential benefits. Here are some of the main differences between CBD and CBG:
CBD (cannabidiol) and CBG (cannabigerol) are both cannabinoids found in the cannabis plant, but they have significant differences in terms of their origin, effects, and potential benefits. Here are some of the main differences between CBD and CBG:
Origin and Biosynthesis
- CBD (Cannabidiol):
- It is one of the most abundant cannabinoids in cannabis.
- It is produced from cannabidiolic acid (CBDA) through a decarboxylation process (removal of a CO2 molecule).
- CBG (Cannabigerol):
- Considered the “mother cannabinoid” because all other cannabinoids are derived from cannabigerolic acid (CBGA).
- In the early stages of cannabis plant growth, CBGA is converted to THCA, CBDA, and other acidic cannabinoids, which are then decarboxylated into THC, CBD, etc.
- In mature plants, the amount of CBG is usually very low, as most of the CBGA has already been converted.

Effects and Benefits
- CBD:
- Known for its non-psychoactive effects.
- Widely used for its anti-inflammatory, anxiolytic, antiepileptic and analgesic properties.
- It may help treat conditions such as anxiety, chronic pain, epilepsy (such as Dravet syndrome and Lennox-Gastaut syndrome), and inflammation.
- CBG:
- It is also non-psychoactive.
- It is being studied for its possible neuroprotective, antibacterial, anti-inflammatory and analgesic properties.
- It can help with conditions such as inflammatory bowel disease, glaucoma (due to reduced intraocular pressure), and bladder problems.
Mechanisms of Action
CBD: Interacts primarily with the endocannabinoid system, but also with serotonin (5-HT1A), vanilloid (TRPV1), and PPARs (peroxisome proliferator-activated receptors). Acts as a negative allosteric modulator of the CB1 receptor and has low affinity for CB2.
CBG: Interacts directly with the CB1 and CB2 receptors of the endocannabinoid system. It can act as an antagonist of the CB1 receptor, which can decrease the psychoactive effects of THC.
What are the benefits of CBG?
Cannabigerol (CBG) offers a variety of potential health benefits. Its anti-inflammatory properties may be useful in treating conditions such as Crohn’s disease and colitis, while its antibacterial properties show efficacy against multidrug-resistant bacteria, including MRSA. Additionally, CBG has demonstrated neuroprotective potential, suggesting benefits in the treatment of neurodegenerative diseases such as Huntington’s disease.
Other benefits include appetite stimulation, useful for patients with loss of appetite, reduction of eye pressure, indicating possible applications in the treatment of glaucoma, and anti-cancer properties, with initial studies suggesting the ability to inhibit the growth of cancer cells, such as those in colon cancer.
Additionally, CBG may relieve pain without psychoactive effects, help treat skin conditions like psoriasis and dermatitis, and possibly modulate mood and anxiety. There is also evidence to suggest that CBG may help relieve symptoms of bladder dysfunction, such as bladder spasms. While these benefits are promising, more clinical research is needed to confirm its efficacy and safety in humans.